منابع مشابه
Effectiveness of dual and triple anti-HIV therapy.
Conflicts of interest: none. The author has already participated as a researcher in multicenter studies on vaccines financed by Whyeth and Merck Sharp Dohme laboratories, and received grants for lectures on immunizations in symposia and scientific meetings sponsored by Whyeth, Merck, Sanofipasteur and GSK laboratories. I would like to make some comments about the original article written by Rom...
متن کاملDual anti-HSV and anti-HIV activity of the lantibiotic Labyrinthopeptin A1
Background It has been shown that genital lesions and altered innate mucosal immunity caused by HSV-2 are important cofactors to increase the rate of HIV transmission and infection. Therefore, a product that inhibits HIV and HSV would have potential benefits in the prophylaxis against these sexually transmitted viruses. The labyrinthopeptin A1 (LabyA1) is a prototype peptide of a novel class of...
متن کاملNovel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action.
We have found that novel pyridine oxide derivatives are inhibitors of a wide range of human immunodeficiency virus (HIV) type 1 (HIV-1) and HIV-2 strains in CEM cell cultures. Some of the compounds showed inhibitory activities against recombinant HIV-1 reverse transcriptase (RT), whereas others were totally inactive against this viral protein in vitro. Partial retention of anti-HIV-1 activity a...
متن کاملA Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity
Human immunodeficiency virus (HIV) infection is often accompanied by infection with other pathogens, in particular herpes simplex virus type 2 (HSV-2). The resulting coinfection is involved in a vicious circle of mutual facilitations. Therefore, an important task is to develop a compound that is highly potent against both viruses to suppress their transmission and replication. Here, we report o...
متن کاملDynamic features of apo and bound HIV-Nef protein reveal the anti-HIV dimerization inhibition mechanism.
The first account on the dynamic features of Nef or negative factor, a small myristoylated protein located in the cytoplasm believes to increase HIV-1 viral titer level, is reported herein. Due to its major role in HIV-1 pathogenicity, Nef protein is considered an emerging target in anti-HIV drug design and discovery process. In this study, comparative long-range all-atom molecular dynamics sim...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2016
ISSN: 1742-4690
DOI: 10.1186/s12977-016-0254-0